The six-time winners kick-started the second round in spectacular fashion, completing a league double over the tax men.
Vipers SC beat the tax collectors of URA FC 2-0 on Tuesday, a repeat of the scoreline witnessed in the reverse fixture.
Second half goals from top-scorer Allan Okello and left back Luyima Enock powered the venoms past the visitors under the tutelage of former coach Alex Isabirye.
A cagey first half of football at St Mary’s Stadium saw both sides pushing for a breakthrough but all ended in vain.
The highlight in the opening 45 minutes was the withdrawal of striker and debutant Isaac Ogwang who picked an injury as a result of a tackle from Godfrey Ssekibengo.
The final stanza under the floodlights was a sigh of relief for the home crowd, with players raising to the occasion.
Nine minutes on return, substitute Kenneth Kimera won a penalty for Vipers after he was brought down in the box by defender Hudu Mulikyi.
Play-maker Allan Okello stepped up, beating URA custodian Omedwa from the spot, taking his tally to 12 goals in the top-flight this season.
Tension growing high, Fans man ot the match Enock Luyima sealed the victory in the 75th minute, with a long-range strike outside the box, assist by the number 9 Kimera.
Vipers SC extended the lead at the top, 4 points ahead of NEC FC who are on 33 while URA FC remained 5th on the log, with 24 points in 16 games.