The Jogoos avenged for the loss they suffered against their strongest rivals during the first round at Hamz Stadium, Nakivubo.
The Kampala derby between SC Villa and Express FC kicked off match day 17 of the Uganda Premier league on Saturday.
The grand opener played at Luzira Prisons Ground ended 1-0 in favor of SC Villa who walked away with the city bragging rights.
Reigning most valuable player Patrick Jonah Kakande scored the decisive goal as the Jogoos returned to winning ways.
For Express, they succumbed to a successive defeat having lost 2-0 to the Eastern giants of BuL FC at home in midweek.
A dull first half of football characterised by few clear-cut chances saw both teams settle for a goalless draw in the first 45 minutes.
After recess, the hosts were rewarded with a penalty following a clumsy challenge on Kakande. The latter capitalized on the moment to put the blues ahead.
Towards the end, Villa goalkeeper Angufindru pulled off a double save after attempts from Basangwa and substitute Gagganga to deny the visitors a late equalizer.
The result extended the Red Eagles search for a league double over Villa. Express last achieved this feat in the 2013/14 season.
Express FC remained fourth on the log, 25 points amassed, one ahead of Villa who moved sixth on the standings.